Prostate treatment medication. Klinikai Központ
University of Kansas Medical Center Rövid összefoglaló The primary objective of this study is to demonstrate that ultra-hypofractionation of prostate cancer does not increase urinary toxicity as defined by the EPIC GU domain patient reported outcome.
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- Urology | Rózsakert Medical Center
- Inpatient care | UD Clinical Centre
- Cypraj a prosztatitis kezelésére
Részletes leírás This is a pilot clinical trial looking at 2 fraction SBRT radiation therapy as an alternative to standard of care. Data does not yet exist for the safety and efficacy of this regimen.
However, the feasibility of ultra-short radiation therapy treatments has already been demonstrated in an analogous treatment using high-dose rate HDR brachytherapy.
HDR brachytherapy has been adopted at high volume cancers centers as a standard treatment for prostate cancer. Typical doses have been 26 - 27 Gy over 2 fractions 13 or Overall, toxicity and efficacy of HDR brachytherapy have compared favorably to other treatment modalities.
HDR brachytherapy was able to achieve higher intraprostatic maximum doses and lower rectal doses, but target volume coverage and urethral dose was not significantly Prostatitis kezelés Bishkek. These data suggest that reducing SBRT treatments from 5 fractions to 2 fractions may be feasible, efficacious and tolerable. Eligible patients include all patients who are otherwise eligible for standard 5 fraction SBRT prostate.
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Study population will be low and intermediate patients with good urinary function as defined by prostate treatment medication prostate volume and low IPSS score. SBRT treatment will be delivered to the prostate treatment medication to Hormonal therapy is permitted on this study.
Rectal sparing with hydrogel spacer SpaceOAR will be encouraged. All patients will be enrolled with interim safety analyses after every occurrence of a grade 3 acute or late toxicity.
Biospecimen and financial toxicity data will also be collected. Átfogó állapot.
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